Anthropic has significantly improved the accuracy of its biology safety filters for Fable 5, reducing the number of false positives by approximately 85 percent. This update allows more biology-related queries to be processed directly within Fable 5, rather than being rerouted to a less capable system. However, restrictions on sensitive topics such as virology and toxicology remain in place. The changes aim to balance the need for safety with the need for efficient processing of legitimate queries. This development matters because it has implications for the development and deployment of AI models in various fields.